Oddsmakers assign odds to each team based on their probability of winning the game. The one thing you should note with NFL moneyline bets is the odds attached to each side. While with points spread bets, you must wager on a team to win or lose by a predetermined number of points, which could complicate the process for new bettors, that is not the case with moneylines. With moneyline bets, you are wagering on the side you believe will win the game straight up. When you bet on an NFL moneyline, you are placing a wager on the most simplistic type of sports betting. For an explanation of our Affiliate Policy, visit this page. Terms apply to the offers listed on this page. We may receive compensation when you click on links to those products. This page contains references to products from one of our advertisers.